Category:Health Impacts and Toxicology
Overview
The Health Impacts and Toxicology category details the medical, epidemiological, and toxicological evidence linking impaired indoor environmental quality to human morbidity. Aligned with EDIAQI Pillar 3 and Work Package 5 (T5.1–T5.4), research focuses particularly on vulnerable populations - most notably children, the elderly, and individuals suffering from chronic respiratory diseases.
This category synthesizes findings from retrospective cohorts (COPSAC2000, COPSAC2010, ATOPICA) and prospective cohorts (SCH2021 Zagreb child asthma cohort, RegionH severe asthma cohort), evaluating how prolonged and episodic indoor exposures drive clinical outcomes, asthma exacerbations, and allergic sensitization.
Research Domains
- Epidemiology and Clinical Studies: Pathophysiology of childhood asthma, allergic rhinitis, atopic dermatitis, and respiratory tract deposition dose measurements.
- Human Biomonitoring: DNA damage and genomic instability assessments in peripheral blood lymphocytes (PBLs) and exfoliated buccal cells using the comet assay and micronucleus (MN) tests.
- Toxicological Evaluation: In vitro (2D monolayer, 3D spheroids, air-liquid interface models in A549 and HepG2 cells) and non-invasive in vivo mammalian models adhering to the 3R principles (Replace, Reduce, Refine).
- Anthropological Perception: Qualitative evaluation of citizen and patient health-risk awareness regarding indoor pollution sources.
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